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12.5 Role of DNA Methylation in Type 2 Diabetes Etiology: Using Genotype as a Causal Anchor

HR Elliott , HA Shihab , GA Lockett , JW Holloway , AF McRae , GD Smith , SM Ring , TR Gaunt , CL Relton

To read the full abstract: Diabetes 2017;66:1713-1722This study examined whether genetic variants predisposing to T2DM exert their influence on disease via changes in DNA methylation in a young, non-diabetic, cross-sectional cohort. The examination of young subjects who are disease-free enables exploration of SNP-methylation relationships without assessing methylation differences that result from rev...

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ey0019.14-7 | Steroidogenesis and beyond | ESPEYB19

14.7. Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

B Ashley , C Simner , A Manousopoulou , C Jenkinson , F Hey , JM Frost , FI Rezwan , CH White , EM Lofthouse , E Hyde , LDF Cooke , S Barton , P Mahon , EM Curtis , RJ Moon , SR Crozier , HM Inskip , KM Godfrey , JW Holloway , C Cooper , KS Jones , RM Lewis , M Hewison , SDD Garbis , MR Branco , NC Harvey , JK Cleal

eLife 2022;11:e71094 doi: 10.7554/eLife.71094Brief summary: Using placental perfusion, placental fragment culture and primary term human cytotrophoblast culture experiments, the authors signify the relationship between maternal vitamin D, placental vitamin D metabolism and fetal vitamin D exposure.In this study, the uptake of radio-labelled vitamin D (13C-25(OH)D...

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ESPE Yearbook of Paediatric Endocrinology

12.5 Role of DNA Methylation in Type 2 Diabetes Etiology: Using Genotype as a Causal Anchor

14.7. Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

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